Malignant Tourette syndrome
Identifieur interne : 002D56 ( Main/Exploration ); précédent : 002D55; suivant : 002D57Malignant Tourette syndrome
Auteurs : Min-Yuen Cynthia Cheung [États-Unis] ; Joohi Shahed [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Attention Deficit Disorder with Hyperactivity (physiopathology), Behavior, Child, Female, Gilles de la Tourette syndrome, Humans, Magnetic Resonance Imaging (methods), Male, Malignant syndrome, Malignant tumor, Malingering (physiopathology), Mental Disorders (physiopathology), Nervous system diseases, Obsessive-Compulsive Disorder (physiopathology), Retrospective Studies, Self injury, Tic, Tourette Syndrome (physiopathology), Tourette syndrome, malignant, self‐injurious behavior, tics.
- MESH :
- methods : Magnetic Resonance Imaging.
- physiopathology : Attention Deficit Disorder with Hyperactivity, Malingering, Mental Disorders, Obsessive-Compulsive Disorder, Tourette Syndrome.
- Adult, Child, Female, Humans, Male, Retrospective Studies.
Abstract
The aim of this work was to draw attention to potentially life‐threatening symptoms associated with Tourette syndrome (TS) and to explore their relationship to TS comorbidities. Medical records of all patients with TS evaluated at our Movement Disorders Clinic between July 2003 and July 2006 were reviewed. Data on patients with malignant TS, defined as ≥2 emergency room (ER) visits or ≥1 hospitalizations for TS symptoms or its associated behavioral comorbidities, were entered into a dataset and analyzed. Five illustrative cases are described. Of 333 TS patients evaluated during the 3‐year period, 17 (5.1%) met the criteria for malignant TS. Hospital admission or ER visits were for tic‐related injuries, self‐injurious behavior (SIB), uncontrollable violence and temper, and suicidal ideation/attempts. Compared with patients with nonmalignant TS, those with malignant TS were significantly more likely to have a personal history of obsessive compulsive behavior/disorder (OCB/OCD), complex phonic tics, coprolalia, copropraxia, SIB, mood disorder, suicidal ideation, and poor response to medications. Although TS is rarely a disabling disorder, about 5% of patients referred to a specialty clinic have life‐threatening symptoms. Malignant TS is associated with greater severity of motor symptoms and the presence of ≥2 behavioral comorbidities. OCD/OCB in particular may play a central role in malignant TS; obsessive compulsive qualities were associated with life‐threatening tics, SIB, and suicidal ideation. Malignant TS is more refractory to medical treatment than nonmalignant TS. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21599
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The aim of this work was to draw attention to potentially life‐threatening symptoms associated with Tourette syndrome (TS) and to explore their relationship to TS comorbidities. Medical records of all patients with TS evaluated at our Movement Disorders Clinic between July 2003 and July 2006 were reviewed. Data on patients with malignant TS, defined as ≥2 emergency room (ER) visits or ≥1 hospitalizations for TS symptoms or its associated behavioral comorbidities, were entered into a dataset and analyzed. Five illustrative cases are described. Of 333 TS patients evaluated during the 3‐year period, 17 (5.1%) met the criteria for malignant TS. Hospital admission or ER visits were for tic‐related injuries, self‐injurious behavior (SIB), uncontrollable violence and temper, and suicidal ideation/attempts. Compared with patients with nonmalignant TS, those with malignant TS were significantly more likely to have a personal history of obsessive compulsive behavior/disorder (OCB/OCD), complex phonic tics, coprolalia, copropraxia, SIB, mood disorder, suicidal ideation, and poor response to medications. Although TS is rarely a disabling disorder, about 5% of patients referred to a specialty clinic have life‐threatening symptoms. Malignant TS is associated with greater severity of motor symptoms and the presence of ≥2 behavioral comorbidities. OCD/OCB in particular may play a central role in malignant TS; obsessive compulsive qualities were associated with life‐threatening tics, SIB, and suicidal ideation. Malignant TS is more refractory to medical treatment than nonmalignant TS. © 2007 Movement Disorder Society</div>
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